The Tuskegee Syphilis Study was initiated because known treatments for syphilis, in 1932, had shown little demonstrated effect, in addition to being toxic and dangerous.
The dependent variable in the Tuskegee Experiment (the knowledge researchers wanted), was whether persons with syphilis were, in fact, better off without the treatment.
We now know that syphilis is curable just treating it with penicillin.
The study is well known, because of the tragedy it caused for many people and also because of the sheer lack of ethical consideration shown by the scientists concerned.
The subjects (participants) were mostly illiterate blacks from Tuskegee, Alabama (USA).
Syphilis is a sexual transmitted disease. It can lead to a range of painful, chronic and deadly symptoms, such as infection in the nerve-system, or cardiovascular-complications.
There are 6 main points which are regarded as highly unethical in the study:
At the beginning of the study, the subjects were not well informed about the whole purpose of the research; neither were they informed of the inherent dangers of the study. The experiment was at the time seen as potentially beneficial for the humankind, but did not consider the harm caused to individuals and their families.
By 1947, Penicillin had become the standard treatment for curing syphilis. Instead of performing the necessary duty; closing the study and giving all of the subjects some penicillin, the scientists of Tuskegee Syphilis Study withheld treatment from many of the participants. The scientists did not follow the commonly used ethical rules of research.
The study ended in 1972, 25 years after the cure was known and publicly available.
By the end of the study, 28 persons had died from the disease, 100 persons had died from related diseases and 40 wives and 19 children had been infected with syphilis.